Introduction to – Ginko Biloba1 Nov 2017
The last survivor of an ancient tree family, Ginko Biloba holds a special place as a nootropic substance. For many years all forms of Ginko were believed to be extinct, that is until small plantations were discovered in Eastern China. It now appears that these Ginko Biloba trees were planted intentionally by monks over a period of a thousand years or more.
The foresight of those monks means that the world now has access to what is a truly prehistoric plant. Most forms of Ginko died out in the Pliocene era, between 1.8 and 5.3 million years ago.
The discovery of Ginko Biloba trees in Eastern China heralded a surge in popularity. Ginko trees can now be found throughout much of Asia where they have proven to be very hardy, especially in high population areas plagued with smog and other forms of pollution. Ginko Biloba trees are so hardy that they were among the very few survivors of the Atom bomb which was dropped on Hiroshima in 1945. In fact, those very same trees which withstood the incredible radioactive explosion that destroyed a generation are still alive and well today.
Ginko Biloba Benefits
Ginko Biloba is regarded by traditional herbalists as being an excellent nootropic capable of enhancing memory and concentration. For this reason it is an ingredient in many energy drinks the world over.
The Science of Ginko Biloba
The science around Ginko Biloba’s effects is murky however. Some studies indicate that it does indeed possess nootropic abilities, others assert that it has little to no effect on human cognitive abilities. Studies have been conducted to determine whether or not Ginko Biloba could be useful in combating Alzheimer’s, and in 2004 conference papers were released which referenced trials indicating that Ginko Biloba may have some potential to aid in the prevention of Alzheimer’s. In 2008 another study concluded that Ginko Biloba had no effect on existing dementia, however.
Of the studies which have returned positive results it would seem that Ginko Biloba has three potential mechanisms of action:
Ginko Biloba Warnings
Because of Ginko Biloba’s potential effects on the body, some people are not good candidates for Ginko Biloba. People who should avoid this plant include those with preexisting blood disorders, particularly those taking blood thinners. Ginko Biloba is also not recommended for pregnant women, nor anyone taking anti depressants.
Potential Side Effects
Though Ginko Biloba is generally considered to be relatively safe for the majority of the population, it can cause the following side effects:
If any of these symptoms are experienced whilst consuming Ginko Biloba, stop immediately and do not resume. Some are more sensitive to Ginko Biloba extract than others.
Introduction to – Caffeine1 Nov 2017
Arguably the most wide spread and popular nootropic, Caffeine is noted for its cognitive enhancement abilities. The clichéd phrase ‘don’t speak to me until I’ve had my first coffee’ and variants thereof are a testament to the power of this perfectly legal drug, which is unregulated in most jurisdictions. The Western world is a particularly large consumer of caffeine, with over 90% of North American adults consuming caffeine on a daily basis.
Some claim that caffeine is not a ‘true’ nootropic because it effects the whole body rather than just the brain, but this would seem to be an argument of semantics. Caffeine is well documented for its action as a psychoactive stimulant.
As a nootropic, Caffeine stimulates short term memory and suppresses long term memory. This means that users of Caffeine may have trouble remembering events which occurred years ago, but will be particularly mentally acute in the exercises they are currently engaging in.
Taken in moderation, caffeine is an excellent nootropic with a relatively gentle but potent effect on its user. Those utilizing caffeine as a nootropic should nevertheless take care to regulate their intake as prolonged heavy use can lead to unpleasant withdrawal symptoms, and extreme overdoses of caffeine can lead to sickness, psychosis and even death.
Withdrawal symptoms also become apparent in those who have become accustomed to taking regular doses of caffeine and then stop. Caffeine tolerance does not take long to develop. Within just four days of ingesting around four espressos per day will cause the body to develop a tolerance to the sleep disturbing effects of caffeine.
Regular caffeine intake leads to increased production of adenosine receptors. The result of this increased production is two fold. Firstly, the user no longer experiences the same effects from caffeine that she or he once did. Secondly, the user becomes more sensitive to adenosine, which is what causes the ‘withdrawal’ symptoms such as headaches, nausea and drowsiness. These symptoms can last for up to 5 days before abating.
The Dark Side of Caffeine
Of course, the effects of over indulging in caffeine can be severe. In nature caffeine protects plants by poisoning and paralyzing insects which try to feed on them. Humans can metabolize small amounts of caffeine without becoming ill, however in very large doses caffeine can cause sickness or even death.
Most people will experience unpleasant side effects long before they approach the point where they dangerously poison themselves or over stimulate their system, if they are ingesting caffeine in its most popular medium, coffee. Those taking high dosage caffeine pills may be less able to predict the effects of the dose before they take it.
The caffeine ‘jitters’ are a sign that an overdose of caffeine has already occurred. The technical term for this phenomenon is ‘caffeine intoxication’. Caffeine intoxication causes anxiety, muscle fluttering, rambling speech, sweating and a rapid heart beat amongst other symptoms. Extreme caffeine intoxication can even lead to psychosis and hallucinations. Lethal doses of caffeine are achieved in humans by consuming the equivalent of 80 to 100 cups of coffee.
Introduction to – Hydergine1 Nov 2017
Nootropics have been widely celebrated in recent years due to their many beneficial effects ion the human body, nervous system and mind. There are many Nootropics substances out there that are widely available, some on prescription, some not.
The benefits of Nootropics drugs vary, but many of them have been used to help treat and/or manage cognitive disorders and ailments. For example, Alzheimer’s disease has been successfully managed (effects wise) through the use of certain Nootropics drugs. Other conditions, such as depression and stroke, have also been tackled with some success through the use of Nootropics substances. It is for this reason that the drugs are becoming more widely used year upon year.
One clear example of Nootropics drugs being used to help the user and their performance in certain tasks has been the widespread use of Nootropics by students in universities and high schools. These students have used such substances to increase their memory and thinking skills overall. The drugs have been proven to enhance performance. Maybe this is because some of the drugs also help with anxiety, but in any case, students are using them in testing conditions and finding that they help to promote academic success.
One of the major Nootropics drugs is Hydergine. This is becoming increasingly popular due to its versatility. It can help with a number of ailments and problems, and is known to have few side effects.
Also known as Ergoloid Mesylates, Hydergine has been used primarily to treat a number of mental disorders. Dementia and Alzheimer’s disease have been successfully treated with Hydergine. This means that that the drug has particular benefit to the older generation of patients. Some of the symptoms of dementia, for example, are very upsetting and disturbing for the patients and the people who are close to them, so Hydergine has been a welcome addition to the care plans of such people.
Hydergine works by dilating the blood vessels in the brain, allowing more oxygen to flow to the brain. This increases capacity for thinking and overall cognitive activity is facilitated.
When it comes to listing or outlining the benefits of Hydergine as a Nootropic, the following benefits are generally cited by studies, and people who use the substance themselves:
The dosage of Hydergine brings benefits at around the 2.25g level. Some people take a higher dose to begin with. If you start a low dose and no effects are noticeable, speak to your physician, who will usually recommend a slow rise in dosage, until you are at a level that brings the desired effect.
As regards side effects, there has been very little in the way of reports of negative side effects. There have been some reports of nausea and gastric upsets, but these are rare.
Obviously, when you take on a new medical programme, tell your doctor, who should be able to advise on dosage and suitability of the drug.
Piracetam and Practicalities1 Nov 2017
Nootropics are a family of drugs whose effects are known to offer great benefit to the human mind, as well as other aspects of the body. Belgian scientist Corneliu Giurgea developed Piracetam in 1964, one of the best known of tees substances.
Part of the Nootropics family, and derived from a substance called GABA, Piracetam has become one of the most famous drugs of this ilk for a very simple reason. It has been shown in a very positive light when discussing the successful treatment of a number of ailments humans suffer, especially those that concern the brain and nervous system.
Coming with virtually no side effects, the drug has been shown to have a positive effect on ailments and illnesses such as Alzheimer’s, heart disease and Cerebral Palsy.
Piracetam acts on the central nervous system. It acts by protecting the cerebral cortex, and preventing a deficiency of oxygen in the brain. The cerebral cortex is responsible for many things when it comes to the operations of the human body, but primarily it plays a role in perception and memory.
Piracetam is available in liquid or tablet form, this makes it one of the more versatile Nootropics out there. People who have taken the substance attest to the benefit in having the option of taking the drug either as a liquid or a tablet.
There are a number of issues that need to be considered before one takes Piracetam. The issues are outlined below:
When you are taking Piracetam, there are a number of things you should be aware of. And remember; always tell your doctor if you have any concerns about any drug you are taking. If your doctor prescribes Piracetam for you, always ensure that you take the drug in exactly the same way the doctor has advised you to.
In addition, you must always read the manufacturer’s information leaflet that comes with the drug. If you can do this before you begin to take the substance, even better.
If you take the solution in the liquid form, you will find that it has quite a bitter taste. Many users find that drinking a glass of fruit juice or water after taking the liquid helps.
Other points to consider:
Some practical considerations as regards Piracetam then. If you have any doubt about taking the drug or the effect it has on you, consult a physician.
Anti Stress Nootropics1 Nov 2017
Nootropics and stress
Stress is one of the most damaging problems that the modern world faces. Becoming more complex and deep-rooted as the pace of the world quickens, the problem has caused many people to suffer, often needlessly. There are certain Nootropics that can be used to lessen the impact of stress.
Stress is simply the effect of the outside world and events upon the person. Sometimes stress can be a good thing, as in competitive sport stress for example. At other times, stress can cripple the minds and bodies of people who are usually rational, clear-thinking individuals.
Public speaking is one of the biggest stressors in modern life. The fact that one has to stand up and present ideas and concepts in front of strangers or even peers is enough to reduce most people to gibbering wrecks.
Studies have shown that stressors can actually cause a variety of neurotransmitters to be released into the body. These transmitters can cause a massive surge of adrenaline to be released, among many other physiological effects. Adrenaline causes a rise in heart rate, and can be quite a stressor in itself.
However, stress is suffered by everyone to some degree. Most times it is not a problem; in fact it is arguable that we all need some stress in order to keep safe. The symptoms of excess stress can cause problems. One of the milder symptoms of stress is that of headaches. Many sufferers of stress complain of headaches, which do not last very long, but can be quite strong.
The more complex symptoms of stress include muscle tension and fatigue. The effect of the adrenaline rush alone can be quite draining, causing tiredness. Then there are the emotional and mental problems that stress can cause. Irritability and mood swings are common problems associated with stress.
More problematic are the behaviours that people under stress can find themselves indulging in. People who suffer from stress are likely to, in the long term, abuse alcohol and drugs. These behaviours cause many problems to the sufferers and the people around them.
Severe medical problems can then result. Even if the sufferer does not indulge in drugs and alcohol, the physical changes that can result from stress can, over time, become quite damaging to the body. Luckily, the Nootropics group of drugs have some impact on stress.
Nootropics can be used to fight stress in one of two ways. The most common way is that of helping people to manage the symptoms of stress and perform better during stressful situations. Nootropics can also be used to lessen the effect of those harmful symptoms that have a capacity to damage the life of the sufferer.
Anxiety is slightly different to stress in that it does not have quite the same impact. Social anxiety is the most common type of anxiety felt. This is what occurs when people find it difficult to enter a crowded room, for example. Other examples are when a person is unable to talk in a social situation, and may require drugs such as alcohol to relax first. Some Nootropics drugs are able to lessen the effects of anxiety, leaving the user able to enjoy social situations without having to rely upon drugs that are less positive.
There are a number of Nootropics that people have found to be useful in the fight against stress. What follows is a short list of those one might want to try. Some people have found that using just one Nootropic is enough. However, others have combined more than one and found the effect to be more dramatic and lasting. Experiment with a variety of Nootropics and doses if you are trying to deal with stress and anxiety, until you find the mix that works for you.
Nootropics that are useful against stress and Anxiety:
Remember to always consult with your doctor before taking on any new course of drugs.
Introduction to ALA – Alpha-Lipoic Acid1 Nov 2017
Introduction to ALA – Alpha-Lipoic Acid
Alpha lipoic acid is a natural compound. It is an antioxidant, genuinely generated by our biological system. It is then spread and is eventually present in each single cell in our body. One of its roles is to convert glucose (blood sugar) into prominent energy. This energy is necessary for us, human, to remain active and in good conditions. Furthermore, antioxidant are matters that perform a vital function of fighting ‘free radicals’, the waste that are produced during the changing of glucose to energy. Alpha lipoic acid avoids free radicals, and ensures better protection of cells. The immune system is thus enforced against infections and other deleterious threats.
In the United State of America, research and clinical studies on human was initiated in the 1970’s trying to find out the benefits of ALA (alpha-lipoic acid) in treating human health problems. The study was carried out by the National Institutes of Health, which was monitored by Burton M. Berkson and Fredrick C. Bartter. An empirical research was administrated on a sample of 79 individuals, who were suffering from acute liver problems or damages. The sample was treated with the use of ALA. Astounding results showed that a total of 75 persons of the total of 79 had completely recovered. The damages were repaired and the functioning of the liver was back to a normal state. Alpha-lipoic acid was afterwards continuingly examined by Dr.Berkson, who had been appointed as member of the FDA. It was concluded that ALA was a proper treatment for chronic liver disease, viral hebatitis and even other illnesses.
Uses of ALA (alpha lipoic acid)
ALA has been identified to be effective in treating a range of health problems. These ranges from:
It is certain that antioxidant medicine treats other health concerns. These are some of its most devised purposes. The effectiveness in treating each of the mentioned health conditions depends upon the dosage. There is no confirmation that it will totally alleviate the health problems. The research on liver damage itself showed some unrepaired cases (4 out of 79). The study highlighted that 4 individuals were not fully recovered after the therapy. However, alpha lipoic acid remains an important drug in treating and alleviating illness, disease and damages inferred on internal cells.
Side effects of ALA (alpha lipoic acid)
ALA does not carry an intense list of adverse effects, but there are some common reactions that are experienced by patients under treatment of alpha lipic acid. These can be:
The progress of research has not yet clearly evaluated whether alpha lipoic acid is convenient for children or pregnant women. Moreover, proper evaluation of the risk associated with the drug, as a dietary supplement or in any other form, requires specialized advises from professional health care providers.
Interaction possibility that exist with ALA (alpha-lipoic acid)
There is always a risk that a negative reaction can be derived from a combination of drugs. It is thus pertinent to consult a health care provider before assuring the consumption of alpha lipoic acid.
Eventually, ALA (alpha-lipoic –acid) does influence the level of blood sugar (glucose) in the body. It decreases the presence of glucose, in respect to its mechanism to increase energy. This is attribute is positive for people who suffer from diabetes. However, if these individuals are consuming other drugs geared towards diabetes, ultimately diminishing blood sugar, then a combined effect can lead to hypoglycemia. It is a situation where a low level of blood sugar is present in the body. It is thus necessary to regulate the level of glucose in correlation to drug intake and availability of blood sugar within the body itself. This would reduce the risk of attaining a situation of hypoglycemia.
Furthermore, ALA can have a negative effect if consumed together with Levothyroxine. The reason for this particular relation is that alpha-lipoic acid tends to decrease the level of thyroid hormone. This particular research is heavily based on animal research. But the effect can absolutely be equal for human.
General information about ALA (alpha-lipoic acid)
Alpha lipoic acid does not need to be consumed. A health body can itself generate sufficient quantities of ALA for the body. However, a body in poor condition can lack the potential to produce the necessary amount.
ALA is mainly generated from the consumption of yeast, meats: especially organs such as liver and red meat. Moreover, the supplement is available in capsules. There is no recommend dosage. The volume will thus be inferred based on treatment purposes. For instance, for diabetes treatment a volume of 800mg daily would probably be assigned. For general intake the volume can be as low as 20mg to 50 mg per day.
What are Nootropics?1 Nov 2017
Nootropics – Cognition Enhancers
Coined in 1964 by Dr Corneliu E Giurgea, the term ‘nootropic’ refers to substances which are alleged to improve human cognitive abilities. Nootropics include drugs, nutrients and herbs. Do they actually work? That largely depends on which nootropic one uses, and ones own perspective. Some scientists and users swear by various types of nootropics, and various types of nootropic are used by the United States Military.
In most cases, nootropics are said to work in one of three fashions, either by stimulating production of neurochemicals in the brain, by increasing oxygen supply, or by stimulating nerve growth.
Some common nootropic drugs include:
Commonly used nootropic herbs include:
From the innocuous to the highly controlled, nootropic substances run the gamut of ingestible materials.
Herbal nootropics have seen a surge in popularity over the last decade with many ‘energy’ drinks containing the herb Ginko Biloba. Ginko Biloba is the last remaining type of a non flowering species, and as such is regarded as being a living fossil. Studies have shown that Ginko Biloba can enhance powers of concentration in healthy individuals, though excessive consumption can cause poisoning in children. Ginko Biloba appears to increase concentration by enhancing blood flow and thereby increasing oxygen flow to the brain.
Caffeine and nicotine are also both widely used nootropic substances which also foster dependence. Most users will find nicotine withdrawal unpleasant, and even caffeine will lead to sometimes severe headaches if discontinued abruptly.
The so called ‘harder’ drugs such as methaphetamine and cocaine are also regarded as being highly addictive. Withdrawing from these substances is a painful process both psychologically and physically.
In spite of these issues, Amphetamines are often used by the military to enhance personnel performance in combat situations. Fighter pilots are actually often required to take ‘go pills’ (amphetamines) in order to keep them alert on long missions. Though these drugs are highly controlled substances amongst civilian populations, they are part of a military person’s required drug regimen and are referred to by the innocuous title ‘fatigue management tools’. The efficacy of these substances cannot be denied, however the consequences of addiction are severe.
If you are seeking to enhance your cognitive performance, nootropic agents may very well be the answer. The trick lies in discovering the right sort of nootropic for your needs.
Nootropics and how they can help
Nootropics are drugs and substances that are believed to be able to enhance cognitive functioning, as well as aid a person’s development. They have been widely used since the 1960’s, and have become famous due to the fact that many students use them to help study. They can also be used in the fight against cognitive problems. Other ailments can also be treated by some Nootropics. In fact, there are so many Nootropics tat a large majority of the problems and medical ailments that mankind suffers from can be managed by the substances.
Some medical conditions that have been treated by Nootropics include:
While Nootropics are not a cure for life’s problems and illnesses, they can certainly alleviate the symptoms of many problems people can face, especially as they age. Occasionally, the underlying cause of the problems can also be treated by Nootropics drugs. In addition, the preventative effect of Nootropics drugs are well documented. This means that many physicians often recommend the use of the drugs to the elderly.
Nootropics have also been used by many people to enhance their performance in certain areas and endeavours. Students have already been referred to in this article. Especially before examinations, when nerves are less than calm, and alertness can be affected by late night study session, Nootropics have proven to be very useful to students. They are generally believed to be a lot safer to use than the more commercial substances that are used for studying, such as Ritalin. While Ritalin is used in schools to help children with hyperactive disorders, students have found, in the past that it can also aid concentration to a high degree. However, the substance is not always entirely safe to use. This is why many university students are now finding Nootropics to be a more attractive alternative. They have a low incidence of side effects, and their ability to improve cognitive functioning makes them the more preferred drug.
When it comes to illnesses like depression, many Nootropics have been found to have an impact. The drugs have been found to elevate mood in some cases. When one considers that there are many drugs on the market that can be sued to counteract depression, and that these drugs do come with considerable side effects, one can see why people would rather use Nootropics drugs.
What is more, some Nootropics can also help with simple anxiety. Social anxiety can cripple people, and stop them for making appropriate gains in social development. Some Nootropics can help with this problem, allowing people to relax and enjoy social occasions without suffering form nerves and shyness.
Nootropics are generally recognised as being extremely safe to use. They have a very low incidence of side effects, and they are not addictive. Many drugs that are use to treat depression, for example, can be addictive. This addiction can have the same negative affect that any other addiction has, and actually compound the problem the drug was originally meant to treat.
Nootropics are becoming very popular in many spheres of medical care. Students like them due to their potential to boost cognitive functioning. People who suffer from depression find them helpful because they alleviate symptoms that are very damaging. And the work that Nootropics can do to help against more serious mental health issues like schizophrenia is invaluable, to the extent that lives can be changed.
Introduction to Picamilon1 Nov 2017
Introduction to Picamilon
Picamilon is classed as a nootropic drug. It is thus geared towards treating several brain disorders such as enhancing vigilance, long term memory, brain trauma, attention and learning issues. Nootropic drugs focuses on progressing the cognitive abilities of the user. Picamilon is considered to be a preferred drug in the class, and it was first introduced in 1986. Moreover, picamilon is mainly made up of two substances which are Niacin (nicotinic acid) and gamma-amino-butyric acid (GABA).
The pharmacological features of the combination of ingredients in picamilon have made it highly popular amidst clinicians. Picamilon is most widely used in respect to its rapid ability to re-establish both physical and mental health. It helps employees who have been exhausted to re-focus on their work. Disturbances developed due to overstress and pressure at the work place is treated with this nootropic drug. Picamilon is considered to be highly effective in rectifying different types of cerebrovascular diseases (related to blood supply in brain). Its’ contribution exceeds that of other drugs such as piracetam, xanthinol and cinnarizine. This has promoted picamilon highly, both in sales and popularity among physicians and clinicians.
Effects and dosage of Picamilon
Picamilon will interact and act promptly in the body. The effects can be noticed within the hour. The drug will be most noticeably sustained for the first 4 to 6 hours. The normally assigned dose of picamilon is 50mg which should be consumed at respected intervals, three times a day. This volume will generate a mood stabilizing effect. A higher dose of 100mg, three times a day, will provide a boost in energy and endurance. The consumption of picamilon produces a cumulative effect. The improvement to health will become transparent after some weeks of usages. Picamilon has limited side-effects with a tremendously low level of toxicity.
Mechanism of Picamilon
Picamilon mechanism is common to other nootropic drugs. It augments the supply of blood while simultaneously enhancing the state of the cognitive functioning of the brain. It does besides improve the microcirculation (Blood flow in the smallest part of the body) and hemodynamics (the force of blood circulation) within various regions in the body. Picamilon does also possess all the prerequisite antioxidant and anti-hypoxic features of other nootropic drugs. These attributes are absolutely sustained in our tissues for an extensive period of time. Moreover, picamilon does not cause sleepiness and myorelacation to the body. It rather simply alleviates the side-effect of burnout-consequences developed from stress that affects our central nervous system.
Uses of Picamilon
Picamilon has proven to be effective in treating several disorders and health problems. The cure varies across cerebrovascular diseases and neurotic disorders. The most direct functions of picamilon have been listed below:
The list of indication of picamilon is expanding rapidly. Clinical studies carried out have found that picamilon have an abundance of additional benefits. The broadening applications of the medicine have proven it to be a success in treating more than the above mentioned health conditions. It does apparently treat health problems such as retina, urination for adults and children, primary open glaucoma and even optic nerves.
General information about Picamilon
Picamilon has safely been used for over 10 years with massive clinical research and trials. Picamilon can be consumed as a medicine and equally as a supplement. It is expected that picamilon alleviates various health concerns not limited to those mention. The capacity of the medicine is pertinent to remain healthy individuals. However, it should be consumed singularly without any other type of related medicine. There is a risk of cross-reaction amidst medicine. It would be most appropriate to consult a doctor for professional advice if the case arises. The physician will be able to assign a proper dose for a specific cure. The strength of the dosage will influence the effectiveness of the therapy, that picamilon will be promoting.
The highest effectiveness of the medicine is achieved once consumed on an empty stomach. It gives the medicine purer power and as a result it generates better results. The results of consuming picamilon are cumulative, thus the highest yield will be seen after some weeks of continuous intake of picamilon.
ALCAR – Acetyl-L-Carnitine
ALCAR (Acetyle-L-Carnitine) is eventually an amino acid that is used by the body to change fat into the form of energy. The human body possesses its own capability of producing essential amount of this substance, carnitine, for our well being. This has eventually hindered proper evaluation upon the need to produce a secondary source of amino acid for our body. Nonetheless, research has depicted that consuming carnitine may boost the ability of tissues to manufacture energy. ALCAR can thus be used to treat health problems related to muscle and heart setbacks.
ALCAR can be generated from normal nutrition consumption. The best sources of carnitine are, however, dairy products and meat. L-carnitine is primarily beneficial to the brain. It does promote the brain’s ability to enhance energy in mitochondrion, which is the part that generates energy for cells. ALCAR (Acetyl-L-Carnitine) has several beneficial results while acting as a cognitive enhancer. It improves different abilities such as memory and mood. This is a derived outcome of its biosynthesis of acetylcholine. The part required for proper internal communication amidst cells in the brain, our neurotransmitters.
Indication of Dosage of ALCAR (Acetyl-L-Carnitine)
ALCAR can be taken as a supplement. In those cases, one or two capsules would be enough. It would in addition be preferable to consume it together with meals that are full of ‘Good Fats’. This will facilitate its absorption in the body. The dosage will, nevertheless, alter in accordance to its therapeutic treatment. The dosage for heart condition or Alzheimer’s disease will range from 200mg to 1000mg. The intake is, as well more frequent, two to three times a day.
Function of ALCAR (Acetyl-L-Carnitine)
Carnitine is used to alleviate predicaments. Its prime use is, nonetheless, to treat problems related to the condition of the heart. There is evidence showing that ALCAR is useful to treat problems such as angina and has successfully acted as a treatment to safeguard the life of people who have previously suffered from a heart attack. A list of other secondary function of acetyl-L-Carnitine has been highlighted below.
Interaction of acetyl-L-carnitine
There are some drugs that will alter the effectiveness of ALCAR. For instance, antiseizure medications such as Depakote or Depakene (valproic acid) reduce the effectiveness of the drug. This means that more carnitine will have to be assigned if such drugs are being concurrently consumed. Moreover, acetyl-L-carnitine should not be consumed simultaneously with thyroid medications unless specified by a professional physician.
General Safety issues concerning acetyl-L-carnitine (ALCAR)
The drug should be prescribed by a doctor. This would certify better qualification for the drug exclusive of unwanted side-effect occurring. The most important aspect is that it shouldn’t be consumed together with thyroid. Special precautions must be considered for pregnant women and young children who are taking the drug. The best option is to go for a low dosage. Furthermore, it is not certain whether ALCAR should be consumed by people who suffer from either a kidney or liver disease.
Introduction to L-dopa (Levodopa)1 Nov 2017
Introduction to L-dopa (Levodopa)
There have been two nobel prizes offered in relation to L-dopa. Arvid Carlsson, received a Nobel Prize in 2000 and in 2001, William S. Knowles earned one-fourth of a Nobel Prize for Chemistry. The substance was found to have strong contribution to the alleviation and treatment against Parkinsonian symptoms. It was found that it tended to hinder the development of the symptoms themselves.
L-dopa (levodopa) was introduced to the market in the 1960s. It has mainly acted as the most appropriate therapy medicine for Parkinson’s disease. Levodopa, itself is a natural matter which is present both in animals and plants. L-dopa works in a specific way. Once it enters our blood it goes through the blood barriers found in the brain and is then decarboxylated. L-dopa is an amino acid which is converted to dopamine, once, in the brain. Levodopa is a precursor to the substance dopamine. The depletion of dopamine provokes Parkinson’s disease. L-dopa does perfectly focus on increasing the level of dopamine and thus as a consequence, it alleviates Parkinsonian symptoms.
Levodopa is sold as a prescribed drug and a dietary supplement in the United State of America. The drug has been administrated to treat Parkinson’s disease but there are also substances found in levodopa making it a marine adhesive (utilized by pelagic life).
Function and Mechanism of L-Dopa
L-Dopa is consumed orally. Once taken, levodopa, the substance will infiltrate into our biological system. It will effectively bypass the “blood-brain barriers”. Instantaneously as the drug crosses the blood-brain barriers it is converted to dopamine. The increasing rectification of the level of dopamine in the brain results in positive effect on our mental health. A higher intensification of dopamine is expected to recover the nerves. This very increase in dopamine assists in the treatment against Parkinson’s disease. However, dopamine is produced in other parts of our body as well. The dopamine produced in the various other parts is highly linked with adverse effects of levodopa.
Side-effects of L-dopa
There are various possible adverse reactions that can be experienced by L-dopa. A list of some of the possible consequences has been highlighted below:
Levodopa is considered to have relatively few side-effects to other drugs created for the same intention such as dopamine agonists and anticholinergics. These drugs carry more deleterious effect in the treatment for Parkinson. Moreover, the volume of the dosage consumed will also be a factor which will highly influence the risk of grapping any negative reactions.
Research on L-dopa
Research has proven l-dopa to be generally safe for humans. The various research has reported a rise in cytotoxicity makers in rats. Another report depicts that an enhancement of the development of ‘quinones’ through a rise in auto-oxidation and subsequent cell death in mesencephalic cell cultures. These are all positive figures drawn from the research upon l-dopa.
Interactions of L-dopa
L-dopa is sensitive to vitamins and other drugs. The presence of vitamine B6 can alter the efficiency of L-dopa. Large dosage of B6 should thus be avoided while consuming L-dopa. This minor problem can be evaded with the consumption of Sinemet. Furthermore, people who are using other drugs such as tyrosine or phenylalanine might be forced to take a higher intake. A Study has depicted that amino acids products compete among themselves and as a consequence the effectiveness of L-dopa is reduced. This can be accommodated by increasing the dosage of levodopa. A similar relation will sustain with high or low level of dietary protein intake. It is preferable to balance the diet in accordance to specifications of the medicine. It is thus necessary to consult a professional doctor before evaluating the necessary dose of l-dopa to be consumed.
General Information about L-Dopa
Levodopa does increase the concentration of dopamine. The consumption of levodopa together with carbidopa assures that l-dopa will properly enter into the brain. Cabidopa does thus allow users to consume lower volumes of the drug. This will restrain the risk of possible side-effects such as vomiting or nausea. The recommended combinations of drugs used together with levodopa are sinemet or atamet consumed concurrently with carbidopa. This is the standard prescription to levodopa.
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